Bone marrow adipose tissue expansion and bone loss in experimental chronic kidney disease is independent of altered bone marrow stromal cell lineage determination.

ABSTRACT:

Introduction

Chronic kidney disease-mineral bone disorder is the irreversible loss of kidney function leading to altered mineral homeostasis and bone loss, commonly referred to as renal osteodystrophy. Bone marrow adipose tissue (BMAT) accumulates in clinical CKD and animal models of this disease, but the mechanism(s) responsible are unclear. This study sought to determine the relationship between BMAT distribution and bone structure and to establish whether disease progression directly affected: 1) the commitment of bone marrow mesenchymal stromal cells (BMSCs) to osteoblastic (OPC) and adipogenic (APC) precursor cells, and 2) the differentiation of BMSCs to mature adipocytes and osteoblasts.

Methods

Eight-week-old male C57BL/6J mice received a diet supplemented with 0.2% a

SUBMITTER: Promruk W 

PROVIDER: S-EPMC12497628 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature