Vagus nerve stimulation combined with ketogenic diet versus ketogenic diet alone in the treatment of febrile infection-related epilepsy syndrome in children: efficacy and long-term prognosis study.

ABSTRACT:

Purpose

To evaluate the clinical efficacy and long-term functional prognosis of vagus nerve stimulation (VNS) combined with ketogenic diet (KD) in the treatment of children with febrile infection-related epilepsy syndrome (FIRES).

Methods

A retrospective analysis was performed on inpatients with a diagnosis of FIRES. They were treated with either VNS + KD (with an interval < 5 days) or KD alone, in addition to standard therapy.

Results

Eighteen children (nine females, nine males) with a median onset age of 8.1 years were studied. Before KD/VNS treatment, the average number of seizures (AS) per hour was 3.0 and the percentage of total duration of electrographic seizures (ESD) per hour was 65.5%. Median duration of anesthesia, duration of mechanical ventilation, and dur

SUBMITTER: Wang T 

PROVIDER: S-EPMC12497667 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature