Integrative analysis by targeted metabolomics revealed the regulatory function of donkey oil on skin metabolites.

ABSTRACT:

Background

Donkey oil, an edible oil rich in unsaturated fatty acids and vitamin E, has the potential to become a multifunctional ingredient for skincare. However, its molecular mechanisms in maintaining skin health remain unknown.

Methods

In this study, 64 volunteers with either healthy or inflammatory skin were divided into two groups and applied donkey oil for 28 days. Then, we measured the targeted metabolites including 65 kinds of organic acids, 94 kinds of amino acids, and 48 kinds of free fatty acids and their derivates in the skin by comparative metabolomics analysis of two groups to assess changes before and after application.

Results

We found differential levels of seven (three upregulated and four downregulated) organic acids in the healthy skin group, six

SUBMITTER: Li M 

PROVIDER: S-EPMC12497717 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature