Metagenomic insights into respiratory viral signatures in lower respiratory tract infections with and without respiratory failure.

ABSTRACT:

Objective

Lower respiratory tract infections (LRTIs) are a significant cause of morbidity and mortality worldwide, with the respiratory microbiome playing a pivotal role in disease pathogenesis. Comprehensive profiling of the lower respiratory tract virome allows investigation of potential differences between LRTIs and non-LRTIs, helps identify virus-associated taxa linked to pulmonary disease, and provides insights into virome-host interactions involved in respiratory health.

Methods

In this study, we compared viral and bacterial microbiome characteristics of LRTI patients with non-LRTI controls by α-diversity, β-diversity (PCoA, NMDS, ANOSIM), and differential abundance (LEfSe) analyses using metagenomic sequencing of bronchoalveolar lavage fluids, and further performed th

SUBMITTER: Zhu N 

PROVIDER: S-EPMC12497718 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature