Preclinical <i>in vivo</i> evaluation of a gonococcal multivalent vaccine containing antigens identified by CASS.

ABSTRACT:

Background

Neisseria gonorrhoeae, causative agent of the human sexually transmitted infection gonorrhea, is a significant global health concern because of increasing antimicrobial resistance and the lack of an effective vaccine. Recent ecological analyses have shown a reduced incidence of gonorrhea in recipients of detergent-extracted outer membrane vesicle (OMV)-containing meningococcal vaccine, which has contributed to identification of shared, protective antigens. Previously, our group has developed an immunobioinformatics-based pipeline (CASS, Candidate Antigen Selection Strategy) for identification of gonococcal hypothetical proteins expressed during human natural mucosal infections, as novel vaccine candidates.

Methods

In this study, we expanded the immunologica

SUBMITTER: Roe SK 

PROVIDER: S-EPMC12497722 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature