<i>Enterocytozoon bieneusi</i> infection disrupts bile acid metabolism in the wild rodent gut microbiota: adaptive shifts in microbial metabolism and community structure.

ABSTRACT:

Introduction

Bile acids (BAs) are central to host-microbiota interactions, yet their metabolism in wild rodents remains poorly characterized. This study aimed to explore the genomic potential of gut microorganisms in wild rodents for BA metabolism and its implications for host adaptation and pathogen interactions.

Methods

We reconstructed 6,332 genomes from the gut microbiota of wild rodents and performed genome-resolved metabolic profiling. Comparative analyses were conducted across host species, including humans, pigs, laboratory mice, and chickens. Functional enrichment was further assessed in relation to glycoside hydrolase families and Enterocytozoon bieneusi infection status.

Results

A total of 5,208 genomes were identified as participants in key BA metabolic pa

SUBMITTER: Shang KM 

PROVIDER: S-EPMC12497767 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature