Extracellular vesicles of patients with acute-on-chronic liver failure induce mitochondrial dysfunction in T cells.

ABSTRACT:

Background and aims

Liver cirrhosis and in particular acute-on-chronic liver failure (ACLF) are characterized by systemic inflammation and dysfunctional immune responses. Extracellular vesicles (EVs) are important mediators of cell stress and inflammation, but their role in ACLF is unclear.

Methods

Phenotype and immune function of EVs of patients with compensated liver cirrhosis, acute decompensation, or ACLF were characterized regarding particle size, concentration, surface markers, and RNA cargo. In addition, functional analyses were performed to assess the impact of EVs on T cells.

Results

EVs of patients with liver cirrhosis showed lower expression of exosome-specific markers (e.g. CD9, CD63, CD81) than EVs of healthy individuals, carried a distinct cargo of prote

SUBMITTER: Langer MM 

PROVIDER: S-EPMC12497775 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature