Reporting of harms in systematic reviews focused on naltrexone: a cross-sectional study.

ABSTRACT:

Background

Naltrexone is a pharmacological intervention widely used for alcohol use disorder (AUD), opioid use disorder (OUD), and several off-label conditions. Systematic reviews (SRs) play a critical role in synthesizing data on the efficacy and safety of such interventions to inform clinical guidelines and decision-making. However, adequate reporting of harms in SRs remains inconsistent, limiting the ability to fully assess the safety profile of naltrexone. This study evaluates completeness of harms reporting and methodological quality in SRs focusing on naltrexone.

Methods

A comprehensive search of MEDLINE, EMBASE, Epistemonikos, and the Cochrane Database of Systematic Reviews was conducted. The study employed masked, duplicate screening and data extraction. Included SRs

SUBMITTER: Schnitker J 

PROVIDER: S-EPMC12497844 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature