CD8⁺ T-NK cell crosstalk establishes preemptive immunosurveillance to eliminate antigen-escape tumors.

ABSTRACT:

Background and objective

Tumor antigen-escape variants undermine immunotherapy by subverting lymphocyte effector functions and reshaping tumor-immune dynamics. It is essential to delineate functional interplay within immune networks during tumor progression. We investigated whether homeostatic crosstalk between CD8⁺T cells and natural killer (NK) cells preempts tumor antigen-escape.

Methods

Adoptive CD8⁺T cell transfers were administered before (D_-7, homeostatic pre-priming) or after (D₊₁) tumor establishment in Rag1^-/- and Rag1^-/-γc^-/- mice. Antigen presentation, immune activation, proliferation, cytotoxicity, and memory were quantified by flow cytometry, live bioluminescence and conf

SUBMITTER: Uzhachenko RV 

PROVIDER: S-EPMC12497863 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature