Anticandidal activity of greenly synthesized silver nanoparticles formulated using Alkanna tinctoria roots against multidrug resistant candidal pathogens.

ABSTRACT: Multidrug-resistant Candida infections demand urgent therapeutic solutions. This study demonstrated the green synthesis of silver nanoparticles designated At-AgNPs using Alkanna tinctoria root extract, showing enhanced antifungal activity against Candida species including resistant C. auris. Characterization confirmed spherical At-AgNPs with 19.91 nm diameter by TEM and 120.6 nm hydrodynamic size, exhibiting a UV-Vis peak at 406.27 nm. EDX analysis revealed 79.24% silver content, while XRD patterns verified face-centered cubic crystallinity. The nanoparticles maintained excellent stability with zeta potential measuring - 23.34 mV and PDI 0.202. At-AgNPs displayed strong antifungal effects, particularly against C. parapsilosis showing 15.46 mm inhibition zone with MIC and MFC values of 1.0

SUBMITTER: Alnahdi KS 

PROVIDER: S-EPMC12497877 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature