Nilotinib hydrochloride monohydrate solubility in supercritical carbon dioxide + cosolvent: measurements and modeling.

ABSTRACT: The solubility of nilotinib hydrochloride monohydrate in supercritical CO₂ was measured at four temperatures between 338 K and 308 K, and seven pressures between 12 MPa and 30 MPa, using ethanol as a cosolvent. Both semi-empirical and empirical approaches were employed to analyze the experimental data. In the ternary systems studied, the solubility values (mole basis) for nilotinib hydrochloride monohydrate were between 1.08 × 10^- 5 and 4.15 × 10^- 4 (10.8 to 415 PPM). The results indicated a significant increase in solubility with the incorporation of ethanol. The peak solubility of nilotinib hydrochloride monohydrate was recorded in the ternary system at 338 K and 12 MPa, which was approximately 10.8 times its solubility in supercritical carbon dioxide alone under id

SUBMITTER: Sajadian SA 

PROVIDER: S-EPMC12497881 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature