Administration of Metoclopramide Prior to Endoscopy for Acute Upper Gastrointestinal Bleeding: A Systematic Review and GRADE Meta-Analysis of Randomized Controlled Trials.

ABSTRACT: Acute Upper Gastrointestinal Bleeding (UGIB) is a critical condition where endoscopy is often hindered by poor visibility. This meta-analysis assesses the safety and efficacy of metoclopramide as a pre-endoscopic aid to improve visualization. Databases including PubMed, Cochrane Library, ScienceDirect, and Google Scholar were searched from inception till October 2024. Review Manager 5.4.1 software was utilized to combine standard and weighted mean differences as well as risk ratios for continuous and dichotomous outcomes, respectively. Quality assessment was carried out by the Cochrane Risk of Bias Tool 2.0. Publication bias was assessed through funnel plots. GRADE assessment was conducted to determine the certainty of the evidence. The protocol of this review was registered on PROSPERO un

SUBMITTER: Waseem MH 

PROVIDER: S-EPMC12497892 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature