Leukocyte count and new-onset diabetes mellitus in people with HIV: A longitudinal study.

ABSTRACT:

Objectives

The risk of diabetes mellitus (DM) is increased in people with HIV. Chronic inflammation contributes to DM risk. High leukocytes are associated with DM in the general population, but in people with HIV, evidence of a leukocyte-DM association is limited.

Methods

We included participants of the Swiss HIV Cohort Study with new-onset DM (2000-2023) and matched controls. We obtained uni- and multivariable odds ratios (ORs) for DM, based on traditional and HIV-related DM risk factors, leukocyte count and potential confounders for leukocyte count.

Results

Among 732 DM cases (median age 54 years, 79% male at birth, 86% with suppressed HIV RNA) and 2032 DM-free controls, the latest leukocyte count prior to DM diagnosis was higher in cases than in controls (median [i

SUBMITTER: Meyer SC 

PROVIDER: S-EPMC12497936 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature