Incidence of and Risk Factors for SARS-CoV-2 Infection Among Vaccinated Healthcare Workers During Emergence of SARS-CoV-2 Gamma Variant in the Amazon Region, Brazil, 2021.

ABSTRACT:

Background

The emergence of new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants poses a significant threat to public health and healthcare workers (HCWs). The SARS-CoV-2 Gamma variant emerged in Manaus, Brazil, in December 2020, leading to a large wave of infections and deaths.

Methods

We conducted a prospective cohort study among HCWs at 2 hospitals in Manaus from 31 March to 31 May 2021. HCWs were followed up for 3 weeks with nasal swabs collected at baseline and weekly (total: 4 visits), regardless of symptoms, for SARS-CoV-2 testing. Blood samples were collected for SARS-CoV-2 serology at baseline. Staff collected data on symptoms, healthcare, and community exposures, and vaccination status at each visit. We evaluated coronavirus disease 2019 (COVID

SUBMITTER: Parra G 

PROVIDER: S-EPMC12497958 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature