Unleashing the immune modulatory potential of <i>Leishmania amazonensis-</i>derived extracellular vesicles in American cutaneous leishmaniasis.

ABSTRACT:

Introduction

American cutaneous leishmaniasis (ACL) constitutes a neglected skin disease that causes severe disability and significant social stigma for millions of people each year. This parasitic infection is caused by several species of the protozoan Leishmania, including Leishmania amazonensis. There is therefore an urgent need to develop effective new tools to control ACL, primarily due to the limitations of current prophylactic and therapeutic strategies, which are exacerbated by the growing burden of the disease and its social impact. In recent years, scientific research has focused on extracellular vesicles (EVs), which are lipid-enclosed rounded nanostructures that carry macromolecules to recipient cells and are part of eukaryotic biology. The role of Leis

SUBMITTER: de Freitas BE 

PROVIDER: S-EPMC12497982 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature