The interaction between obesity and sex alters the response to house dust mite in an experimental model of allergic lung inflammation.

ABSTRACT:

Introduction

Previous reports have shown that the prevalence of asthma among women is modified by puberty, implying a role for sex hormones in this difference. Additionally, it has been demonstrated that obesity is a significant predisposing factor for asthma, particularly among women. In this regard, populational studies have suggested that severe asthma is more prevalent among obese patients, with worse symptoms, frequent exacerbations and hospitalisations among these patients. This study aimed to elucidate how sex and obesity interact in a murine model of lung allergic inflammation induced by house dust mite (HDM) in male and female animals.

Methods

Male and female C57Bl/6 mice were maintained on a 60% high-fat diet (HFD) or a standard chow diet (SC) for 13 weeks, and on

SUBMITTER: Santos-Cavalcante A 

PROVIDER: S-EPMC12498017 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature