Chemical Synthesis and Structural Determination of the Inositol Glycan Head of Plant Sphingolipid GIPC in Brassicaceae.

ABSTRACT: Glycosylinositol phosphoceramides (GIPCs), a major class of plant sphingolipids, are key components of the plasma membrane and play important roles in plants. These molecules consist of a ceramide 1-phosphate tail attached to an inositol glycan (IG) head, which typically contains an d-glucuronic acid (GlcA)-α(1→2)-myo-inositol structure. The second monosaccharide linked to the O-4 position of the GlcA residue differs depending on plant species and cell tissues. In Arabidopsis, the predominant second monosaccharide has been identified as hexose (Hex) using LC-MS/MS analysis. However, the stereochemistry and anomeric configuration of the Hex have not yet been determined using spectroscopic techniques. In this study, we chemically synthesized three different Hex-type IGs in which the GlcA res

SUBMITTER: Umemura Y 

PROVIDER: S-EPMC12498067 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature