Prospective evaluation of CAR-T cell therapy-related proteinuria and kidney dysfunction.

ABSTRACT:

Background

The nephrotoxicity of chimeric antigen receptor T-cell (CAR-T) therapy has been reported, yet data on urinary abnormalities remain limited. This study aimed to characterize proteinuria, acute kidney injury (AKI), and associated electrolyte disorders in patients treated with CAR-T therapy.

Methods

A prospective analysis was conducted on 63 patients treated with CAR-T therapy between June 2020 and December 2023. Blood tests were collected daily during hospitalization and a first morning urine void was collected on day of infusion (D0), +7 (D7), and +14 (D14).

Results

During the study period, 12 patients (19%) developed AKI. The median urine protein-to-creatinine ratio (uPCR) increased significantly from 0.17 g/g on D0 to 0.39 g/g on D7, returning to baseline

SUBMITTER: Moncho-Frances F 

PROVIDER: S-EPMC12498094 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature