Frailty subtypes and white matter alterations in older adults without dementia.

ABSTRACT:

Aim

Frailty increases the risk of cognitive decline in older adults, yet the brain structural patterns associated with different frailty subtypes remain unclear. This study examined white matter (WM) alterations across frailty subtypes in community-dwelling older adults without dementia.

Methods

This cross-sectional study included participants from the Taiwan Precision Medicine Initiative on Cognitive Impairment and Dementia (TPMIC) cohort. Frailty was assessed using Fried's phenotype and classified into mobility, non-mobility, and low physical activity subtypes. Cognitive function (attention, memory, and executive function) was evaluated using standardized neuropsychological tests. WM microstructure was measured using diffusion tensor imaging (DTI) metrics, including fracti

SUBMITTER: Lin CH 

PROVIDER: S-EPMC12498124 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature