Manganese-based nanotheranostics synergizing photothermal-chemotherapy for liposarcoma treatment.

ABSTRACT: Liposarcoma (LPS), the most common subtype of soft tissue sarcoma, presents significant therapeutic challenges due to its high heterogeneity, frequent recurrence, and adverse effects on conventional treatments. In this study, we developed multifunctional manganese-based nanotheranostics by integrating Mn₃O₄ nanoparticles (Mn₃O₄ NPs), doxorubicin (DOX), and photosensitizer IR-780, with surface modification using polydopamine (PDA). The manganese-DOX-IR-780 nanoparticles (MDI NPs) exhibited a uniform particle size distribution, excellent colloidal stability, biocompatibility, and pH-responsive drug release capability. Additionally, they achieved efficient photothermal heating, reaching temperatures of 70-80 °C, with a photothermal conversion effici

SUBMITTER: Zhan W 

PROVIDER: S-EPMC12498137 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature