A Photocaged N-Phosphonopiperidinone as a Selective Photo-Cleavable DPP8/9 Inhibitor.

ABSTRACT: The strategic introduction of photocages into chemical probes represents a powerful approach to generate spatiotemporally controlled tools with promising applications in chemical biology and drug discovery. This approach is particularly useful for inhibitors of proteins with cell-type-dependent functions, as they enable, via light-triggered selection, the study of their function in selected cells within multicellular organisms. The intracellular dipeptidyl peptidases 8 and 9 (DPP8/9) are serine hydrolases that act in a cell type-dependent fashion, in diverse biological processes such as inflammation and tumorigenesis. So far, no photocaged inhibitors for DPP8/9 are available, thus hampering their systematic investigations in biomedical research model systems such as mice. Herein, the devel

SUBMITTER: Sewald L 

PROVIDER: S-EPMC12498190 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature