Non-invasive high frequency oscillatory ventilation for primary respiratory support in extremely preterm infants: multicentre randomised controlled trial.

ABSTRACT:

Objective

To test the hypothesis that non-invasive high frequency oscillatory ventilation (NHFOV) is more efficacious than nasal continuous positive airway pressure (NCPAP) in reducing invasive mechanical ventilation as primary respiratory support for extremely preterm infants with respiratory distress syndrome.

Design

A multicentre, randomised controlled trial.

Setting

Twenty tertiary neonatal intensive care units in China.

Participants

342 extremely preterm infants (gestational age between 24 weeks +0 day and 28 weeks +6 days) with respiratory distress syndrome were enrolled in the study between August 2022 and August 2024.

Interventions

Participants were randomly allocated to receive NCPAP or NHFOV as primary respiratory support for respiratory distre

SUBMITTER: Li Y 

PROVIDER: S-EPMC12498197 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature