Polyacrylamide functionalized polysaccharide based nanocomposite semi-interpenetrating polymeric network hydrogel for pH-responsive controlled release of a model neuroprotective drug.

ABSTRACT: The development of advanced drug delivery systems with enhanced stability, controlled release, and biocompatibility is critical for effective neuroprotective therapies. Here, we report a polyacrylamide-functionalized polysaccharide-based nanocomposite semi-interpenetrating polymer network (semi-IPN) hydrogel designed for pH-responsive delivery of the neuroprotective agent citicoline. The semi-IPN structure provides enhanced mechanical strength and tunable swelling, enabling precise and sustained pH-responsive drug release while minimizing burst effects. SEM analysis revealed a porous microstructure that facilitates efficient drug loading and diffusion, and XRD confirmed a semi-crystalline architecture contributing to mechanical stability. Cytotoxicity studies using 3T3 fibroblasts demonstr

SUBMITTER: Aljarba NH 

PROVIDER: S-EPMC12498329 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature