Exercise-mediated amelioration of high-fat diet-induced kidney injury: implications of microRNA regulation.

ABSTRACT: Obesity-related kidney injury has become a critical health concern, driven by metabolic disturbances, chronic inflammation, oxidative stress, and structural remodeling. While exercise is widely recognized for its broad health benefits, including its ability to mitigate obesity-related complications by improving metabolic homeostasis, reducing inflammation, and enhancing antioxidative capacity, its specific role in protecting renal function - particularly through the modulation of microRNAs (miRNAs) - remains insufficiently understood. This study investigated the effects of an 8-week moderate-intensity treadmill exercise intervention on high-fat diet (HFD)-induced kidney injury in a murine model. Chronic HFD feeding resulted in significant renal dysfunction, evidenced by elevated filtration

SUBMITTER: Luan Y 

PROVIDER: S-EPMC12498360 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature