Palladium-Catalyzed Asymmetric Carbonylation of Alkynes to Axially Chiral Carbothioate Esters.

ABSTRACT: Herein, we report a novel palladium-catalyzed asymmetric hydrothioesterification of alkynes under mild conditions, enabling the precise construction of axially chiral carboxylic thioester derivatives with excellent yields, regioselectivity, E/Z selectivity, and enantioselectivity. Disulfides and thiosulfonates were applicable, as well.

SUBMITTER: Yao W 

PROVIDER: S-EPMC12498392 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature