Mechanism Inversion in Visible Light-Induced Photoclick Reactions.

ABSTRACT: Photoclick chemistry has emerged as a powerful methodology for achieving precise spatial and temporal control in photochemical transformations, enabling various applications ranging from surface functionalization, polymer conjugation, and photo-cross-linking to bioimaging and protein labeling. Despite significant advances, the absence of an unambiguous structure-property-mechanism relationship limits the design and application of photoclick systems in biological and material contexts. Herein, we report a novel strategy for tuning the reactivity and reaction mechanism of photoclick reactions of 9,10-phenanthrenequinone (PQ) with electron-rich alkenes (ERAs) through the design of 2,2'-substituted PQ derivatives incorporating electron-withdrawing groups (EWGs) and electro

SUBMITTER: Fu Y 

PROVIDER: S-EPMC12498399 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature