The Influence of POPC as a Coaggregate in Amyloid-β Oligomer Formation.

ABSTRACT: Alzheimer's Disease (AD) progresses with the formation of neuronal plaques composed primarily of the 42-residue alloform of amyloid-β (Aβ₄₂), whose oligomeric forms induce cytotoxicity by interacting with neuronal membranes, resulting in permeabilization and calcium ion leakage. In AD, elevated phospholipase activity disrupts lipid homeostasis and may increase the concentration of free lipids, such as 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC), in extracellular environments proximal to the membrane surface, potentially promoting Aβ₄₂ insertion and toxicity. The coaggregation of Aβ₄₂ with free lipids is believed to modulate mechanisms underlying Aβ₄₂-induced cytotoxicity; however, these interactions are poorly understood. Molec

SUBMITTER: King KM 

PROVIDER: S-EPMC12498404 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature