Influence of induction therapy and antiretroviral regimen on outcomes in kidney transplant recipients living with human immunodeficiency.

ABSTRACT:

Purpose

Kidney transplantation has a survival benefit for people with human immunodeficiency virus (HIV) and end-stage kidney disease, however increased rates of rejection remain an issue. Questions remain regarding the impact of induction immunosuppression therapy and antiretroviral (ARV) choice on long-term outcomes.

Methods

We performed a multicenter retrospective analysis of outcomes in recipients with HIV who received kidneys from donors without HIV transplanted between 2004 and 2019. The association between induction and ARV regimens and long-term outcomes including rejection, graft, and recipient survival over 5 years was investigated using Cox regression modeling.

Results

Seventy-eight kidney transplants (KT) performed in 77 recipients at five US transplant ce

SUBMITTER: Marks CR 

PROVIDER: S-EPMC12498429 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature