A nucleoporin-associated signaling cascade controls plant immunity via histone modification.

ABSTRACT:

Background

Plants undergo massive transcriptional reprogramming upon pathogen infection. The transcription factors SAR DEFICIENT1 (SARD1) and CAM-BINDING PROTEIN 60-LIKE G (CBP60g) are master regulators of this process. However, the regulation of SARD1 and CBP60g transcription remains unclear.

Results

We discover a signaling complex centered on the plant-specific nucleoporins CONSTITUTIVE EXPRESSION OF PR GENES 5 (CPR5) and GUANYLATE-BINDING PROTEIN-LIKE GTPASE 3 (GBPL3), which critically regulates SARD1 and CBP60g transcription. We establish that the RNA processing complexes NineTeen Complex (NTC) and CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR (CPSF) act downstream of CPR5 to activate immunity. A genetic screen identifies GBPL3 and key histone modification complex comp

SUBMITTER: Pan L 

PROVIDER: S-EPMC12498470 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature