Efficacy and Safety of Topical Dapsone in Dermatology: A Scoping Review of Clinical Studies.

ABSTRACT:

Background

Dapsone (4,4'-Diamino diphenyl sulfone) has been utilized in managing a wide variety of mucocutaneous conditions, usually as a systemic product. Topical dapsone is commercially available as 5% and 7.5% gel and is FDA-approved for acne vulgaris. These topical formulations have shown less systemic absorption and fewer adverse events. Considering this, topical dapsone might benefit localized disease, immunosuppressed individuals, and those who avoid exposure to systemic therapies.

Methods

Following PRISMA guidelines, a comprehensive literature search was conducted across PubMed, Web of Science, and Scopus databases for published papers up to April 2025. Then, eligible studies are included, and we summarize the findings of different clinical studies concerning the use

SUBMITTER: Abtahi-Naeini B 

PROVIDER: S-EPMC12498492 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature