Tracking carboplatin chemoresistance in ovarian cancer by scanning electrochemical microscopy.

ABSTRACT: Drug resistance in cancer presents a significant challenge in oncology, contributing to most chemotherapy failures. Early detection of drug resistance is crucial for improving treatment outcomes. Ovarian cancer is often treated with platinum-based drugs, such as carboplatin (CBDCA), but unfortunately, resistance to these compounds is common. The exact mechanisms behind platinum-based drug-resistance remain unclear. This research demonstrates the use of scanning electrochemical microscopy (SECM) to track the cellular response to chemotherpeutic exposure through the quantification of glutathione, a cellular antioxidant, as a biomarker for cellular drug resistance. In the presence of the redox mediator ferrocenemethanol, SECM successfully tracks differential cell redox behaviours in CBDCA-sus

SUBMITTER: Daou R 

PROVIDER: S-EPMC12499268 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature