Deciphering the Acetabular Labrum's Cellular Atlas: MDK Inhibition as a Novel Therapeutic Method for Developmental Dysplasia of the Hip.

ABSTRACT: DDH is far more than just a contributing factor to hip osteoarthritis; it represents a formidable challenge to the health of infants and young children. While historical research has largely focused on the osseous abnormalities associated with DDH, current surgical interventions, though prevalent, often carry significant and unavoidable side effects. To break through these limitations, the study delved into the acetabular labrum, a crucial intra-articular structure that presents abnormalities in DDH patients. Through single-cell combined spatial transcriptomic analysis of the acetabular labrum under diverse conditions, a comprehensive examination of the changes of DDH tissue changes at the single-cell level is pioneered, conclusively linking aberrant fibrocartilage stem/progenitor cell pro

SUBMITTER: Yang R 

PROVIDER: S-EPMC12499403 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature