Genetic Evidence Supporting a Role for Brain Region Volume and Functional Network Alterations in Major Depression.

ABSTRACT: Despite emerging evidence of altered brain region volumes and functional networks in major depression (MD), causal relationships remain unexplored. Here, using genetic variants related to human brain morphometry (n = 36778) and functional networks (n = 47276), bidirectional two-sample and multivariable Mendelian randomization (MR) is performed to systematically investigate causal relationships between 83 brain-wide volumes, 191 resting-state functional magnetic resonance imaging phenotypes, and MD to identify core brain region volumes and functional networks associated with MD onset. Unlike other severe psychiatric disorders, reductions in left and right ventral diencephalon and thalamus volumes, together with decreased functional connectivity between the precuneus, cuneus, or cingulate gy

SUBMITTER: Xu MM 

PROVIDER: S-EPMC12499405 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature