Targeting Hyperglycemic Bone Pre-Metastatic Niche for Breast Cancer Bone Metastasis Therapy.

ABSTRACT: Bone is the most common site of breast cancer metastasis, yet understanding the intricate mechanisms and potential therapeutic targets remains nascent. Here it is reported that breast cancer establishes a hyperglycemic bone pre-metastatic niche before migrating to bone tissue and further enhances glucose metabolism following metastatic colonization. An intervention strategy is subsequently proposed targeting glucose metabolism utilizing a biomimetic-engineered enzyme-based nanoplatform. This platform's membrane shielding reduces the interaction between engineered glucose oxidase and circulating glucose, while the engineered enzyme specifically targets glucose metabolism, enabling self-amplifying starvation combined with selective chemotherapy. Such precision can precisely inhibit breast ca

SUBMITTER: Ye J 

PROVIDER: S-EPMC12499427 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature