Parvalbumin Interneuron-Dependent Hippocampal Neurogenesis Evoked by Prolonged Rhythmic Light Flicker.

ABSTRACT: Rhythmic light flicker alleviates cognitive impairments in various animal models of neurological diseases. However, its long-term effects and underlying mechanisms remain unclear. Here, a cohort of adult mice is subjected to long-term exposure to 40 Hz light flicker (1 hour daily for 30 days) and observed significant enhancements in hippocampal neurogenesis and spatial learning without any adverse behavioral effects. Specific ablation of hippocampal newborn neurons using DCX^DTR mice abolished these effects. Furthermore, the inactivation or elimination of GABAergic parvalbumin (PV) interneurons not only impaired 40 Hz light flicker entrainment but also reduce neurogenesis in the dentate gyrus (DG). Long-term flicker exposure increases excitatory input to DG PV interneurons, which

SUBMITTER: Yan H 

PROVIDER: S-EPMC12499440 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature