Supramolecular Lubricating Hydrogel Microspheres Reshape Damaged Matrix Regeneration.

ABSTRACT: Supramolecular lubrication refers to lubricant supplementation utilizing intermolecular noncovalent interactions to remodel lubrication structure at biological interfaces. The previous studies found that lubrication supplementation is closely related to damaged matrix regeneration, but the lubrication structure is prone to disintegration and failure. Here, combining with microfluidic and photopolymerization strategies, a supramolecular lubricating hydrogel microsphere is constructed, which is medicated by dipalmitoylphosphatidylcholine (DPPC) liposomes as the core, a natural component in body fluids, and complexed with cartilage matrix-binding peptide functionalized methacryloylated hyaluronan acid (WYR-HAMA) as the photoinitiated site. The highly intermolecular ion-dipole interaction betw

SUBMITTER: Yuan H 

PROVIDER: S-EPMC12499493 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature