Pharmacokinetics of (6S)-5-Methyltetrahydrofolate dicholine salt compared to folic acid: a randomized double-blind single dose cross-over study.

ABSTRACT:

Background

(6S)-5-Methyltetrahydrofolate ((6S)-5-MethylTHF) is the physiological folate form in biological fluids. Salts of (6S)-5-MethylTHF may have advantages compared to folic acid and are increasingly used in foods and supplements.

Objective and design

The present study describes the physicochemical properties of the (6S)-5-MethylTHF-2Chol salt as a source of methylfolate with respect to solubility, conductivity, and melting point. The pharmacokinetics of (6S)-5-MethylTHF-2Chol and folic acid were compared in a randomized controlled double-blind cross-over study using a single equimolar oral dose of each of the folate substances.

Results

The solubility of the dicholine salt was very high (650 mg/mL in H₂O and 40 mg/mL in H₂O under acidic cond

SUBMITTER: Schon C 

PROVIDER: S-EPMC12499688 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature