The Role of Rapid Eye Movement Sleep in Neural Differentiation of Memories in the Hippocampus.

ABSTRACT: When faced with a familiar situation, we can use memory to make predictions about what will happen next. If such predictions turn out to be erroneous, the brain can adapt by differentiating the representations of the cue from the mispredicted item itself, reducing the likelihood of future prediction errors. Prior work by Kim, G., Norman, K. A., and Turk-Browne, N. B. Neural differentiation of incorrectly predicted memories. Journal of Neuroscience, 37, 2022-2031 [2017] found that violating a sequential association in a statistical learning paradigm triggered differentiation of the neural representations of the associated items in the hippocampus. Here, we used fMRI to test the preregistered hypothesis that this hippocampal differentiation occurs only when violations are followed by rapid e

SUBMITTER: McDevitt EA 

PROVIDER: S-EPMC12499895 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature