Microbiome in Early Childhood Caries: Caries Severity-Dependent Insights.

ABSTRACT:

Introduction

Children with early childhood caries (ECC) show different caries severities and susceptibility in different tooth types and location in the oral cavity. The study aimed to investigate differences in the oral microbiome in ECC subjects stratified according to the severity of caries and between more and less caries-prone teeth within the same subjects.

Methods

Supragingival plaque from the upper and lower anterior regions in the oral cavity of subjects were collected in 3 groups of increasing caries severity: G1 - molar (M) caries only; G2 - molar and upper anterior (UA) caries; and G3 - M + UA + lower anterior (LA) caries followed by microbiome analysis.

Results

Alpha-diversity analyses showed inter- but no intra-individual statistically significant differ

SUBMITTER: Gong SG 

PROVIDER: S-EPMC12500261 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature