Adult-onset type 1 diabetes: predictors of major cardiovascular events and mortality.

ABSTRACT:

Background and aims

The prognosis of adult-onset type 1 diabetes (T1D) and prognostic factors are sparsely investigated. This study assessed mortality, major adverse cardiovascular events (MACE), and prognostic factors in adult-onset T1D, particularly focusing on those diagnosed at age ≥40.

Methods

Participants were people diagnosed with adult-onset T1D (n = 10 184) or type 2 diabetes (T2D, n = 375 523) in 2001-20 from the Swedish National Diabetes Register and 509 172 population controls from the Total Population Register, followed until 2022. Hazard ratios (HR) and population attributable risk fraction (PAR%) were estimated.

Results

People with T1D had higher incidence of MACE (HR 1.30 [95% confidence interval 1.17, 1.45]), all-cause mortality (1.71 [1.60, 1.84]), a

SUBMITTER: Wei Y 

PROVIDER: S-EPMC12500326 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature