Sex-dependent impairment of antibody responses to tick-borne encephalitis virus vaccination and infection in obese mice.

ABSTRACT: Obesity is a growing global health concern with profound effects on immune function and vaccine efficacy. This study investigated the impact of obesity on immune responses to tick-borne encephalitis virus (TBEV) vaccination and infection using a mouse model. Mice on a high-fat diet (HFD) exhibited increased body weight, fat mass and a pre-diabetic state compared to standard chow diet (SCD) controls. After vaccination with the TBEV vaccine (Encepur), HFD mice showed significantly lower TBEV-specific IgG litres and neutralizing antibody levels compared to SCD mice. Splenocyte counts per organ mass were significantly higher in vaccinated SCD mice compared to their HFD counterparts, correlating with the elevated IgG litres observed in the SCD group. These results underscore the critical role o

SUBMITTER: Dvorak M 

PROVIDER: S-EPMC12500394 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature