Zerumbone Attenuates Lipopolysaccharide-Induced Acute Lung Injury by Suppressing the NLRP3/Caspase-1/GSDMD Signalling Pathway.

ABSTRACT: A cyclic sesquiterpene with 11 carbon atoms is the primary component of essential oils from the wild ginger species, Zingiber zerumbet. It exhibits pharmacological effects, including anti-inflammatory and antioxidant properties. However, limited information exists regarding its role in pyroptosis during acute lung injury (ALI). Herein, we investigated how zingerone affects pyroptosis in a murine lipopolysaccharide (LPS)-induced ALI model established via intraperitoneal zerumbone (Zer) administration. Bronchoalveolar lavage fluid, serum, and lung tissue samples were collected after 24 h. Haematoxylin and eosin staining was performed to assess lung tissue damage. Western blot analysis and real-time quantitative polymerase chain reaction (qRT-PCR) were used to quantify protein expression leve

SUBMITTER: Xu YJ 

PROVIDER: S-EPMC12500414 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature