The Flavonoid Kaempferol Mitigates Periprosthetic Osteolysis by Regulating the NLRP3 Inflammasome and Balancing Bone Metabolism.

ABSTRACT: Total joint arthroplasty (TJA) is an effective intervention for end-stage arthritis; however, its long-term success is often compromised by wear particle-induced osteolysis, leading to aseptic loosening and implant failure. This study investigates the potential of kaempferol (Ka), a natural flavonoid with anti-inflammatory properties, to alleviate osteolysis by modulating NLRP3 inflammasome activation. In a murine calvarial osteolysis model, Ka administration significantly attenuated bone loss induced by CoCrMo alloy particles. Mechanistically, Ka dose-dependently inhibited NLRP3 inflammasome activation in macrophages, as evidenced by reduced IL-1β secretion, decreased ASC oligomerisation and suppressed GSDMD cleavage, ultimately leading to decreased pyroptosis. These effects were found to

SUBMITTER: Huang C 

PROVIDER: S-EPMC12500419 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature