Androgen receptor activation promotes tumor progression in canine and human triple negative breast cancer cell lines.

ABSTRACT:

Introduction

Triple negative breast cancer (TNBC) is an aggressive type of breast cancer that lack of expression of hormonal receptors and HER-2 that limits the approach of effective therapies. Currently, the expression of the androgen receptor (AR), and its prognostic potential are being explored in these tumors. Therefore, this study aimed to determine the mechanisms of action of AR in TNBC and the potential of AR antagonists as treatment in canine (IPC-366) and human (SUM149) TNBC cell lines.

Methods

To achieve this, AR silencing assays were performed to determine evaluate the changes in AR signaling and the role of AR in cellular processes. Also, the effect of different AR-antagonists was evaluated on both cell lines.

Results

The findings showed that AR promotes t

SUBMITTER: Caceres S 

PROVIDER: S-EPMC12500424 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature