Association of triglyceride glucose body mass index with osteoporosis risks in a large Chinese adult cohort.

ABSTRACT:

Background

Insulin resistance (IR) is implicated in bone metabolism dysregulation, but the role of Triglyceride Glucose Body Mass Index (TyG-BMI), a surrogate marker integrating lipid-glucose metabolism and adiposity, in osteoporosis risk remains underexplored.

Methods

We analyzed 23,930 participants categorized into TyG-BMI quartiles (Q1-Q4). Baseline characteristics, biochemical profiles, and medication use were compared. Osteoporosis incidence was tracked over a 4-year median follow-up. Cox models estimated hazard ratios (HRs) for osteoporosis across quartiles of TyG-BMI, adjusted for confounders. Stratified analyses were performed to explore the effect modification by age, sex, renal function, smoking, and medication use.

Results

Osteoporosis incidence (1,134 case

SUBMITTER: Liu H 

PROVIDER: S-EPMC12500458 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature