Elucidating the causal role of age of menarche, adiposity, lipid fractions, and blood pressure upon cardiovascular disease: a multivariable Mendelian randomization study.

ABSTRACT: This study explores the causal role of multiple correlated risk factors in coronary heart disease (CHD) and ischemic stroke, using Mendelian randomization (MR) analyses with GWAS summary data from both prevalent and incident stroke cases. Thirteen candidate risk factors were considered, including age at menarche, adiposity, lipid fractions, blood pressure, and smoking. Univariable MR identified seven exposures significantly associated with CHD risk, including BMI, blood pressure, LDL, triglycerides, type-II diabetes, and smoking. Notably, HDL showed a protective effect (OR = 0.77, 95% CI: 0.72-0.83), while type-II diabetes was positively associated with CHD (OR = 1.10, 95% CI: 1.05-1.16). For ischemic stroke subtypes, diastolic and systolic blood pressure showed consistent effects across b

SUBMITTER: Jee Y 

PROVIDER: S-EPMC12500469 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature