Malignant progression of MES-like cells mediated by COL22A1 in the spatial heterogeneity of glioblastoma.

ABSTRACT: Glioblastoma (GBM), a highly aggressive malignant brain tumor, leads to poor clinical outcomes and low long-term survival rates. Using bioinformatics approaches, we analyzed single-cell RNA sequencing (scRNA-seq) data (GSE273274) from glioma patient samples in this study. It was found that mesenchymal-like (MES-like) cells in the GBM center (GC) significantly facilitated GBM's aggressive spread and microenvironmental reprogramming. Further analysis on MES-like cells suggested that these cells may participate in the progression from glial differentiation to invasive metastasis. Differential expression analysis, univariate Cox regression, and LASSO regression identified COL22A1 as a key gene. COL22A1 was highly expressed in GC compared to GBM surrounding tissue (GS) and exhibited potential c

SUBMITTER: Chen G 

PROVIDER: S-EPMC12500492 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature