Quantitative analysis of serum metabolites in a rat model of Alzheimer's disease.

ABSTRACT:

Objective

OXYS rats are a unique animal model of sporadic Alzheimer's disease (AD) that demonstrates all the key signs of AD in humans. Studying metabolic processes in OXYS rats in comparison with control Wistar rats can contribute to understanding the mechanisms of AD development, as well as to establishing metabolomic biomarkers of AD. The main goals of the work are to establish differences in the metabolomic profiles of OXYS and Wistar rat serum at different stages of AD-like pathology (presymptomatic, early and late).

Methods

NMR-based metabolomics was applied for metabolomic profiling of blood serum of OXYS and Wistar rats at the age of 20 days (presymptomatic period), 4 months (first manifestation of signs of AD) and 16 months (active development of signs).

Results<

SUBMITTER: Smolentsev AA 

PROVIDER: S-EPMC12500553 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature