Trajectory of the systemic immune-inflammation index and in-hospital mortality in patients with sepsis.

ABSTRACT:

Background

Sepsis is a complex systemic inflammatory response syndrome triggered by infection with high morbidity and mortality. The systemic immune-inflammation index (SII) is a biomarker of inflammation and immune status. This study investigated the relationship between the SII trajectory and in-hospital mortality in patients with sepsis.

Methods

This retrospective study included 1015 adults who were admitted via the emergency department of the First Hospital of Jilin University with a first episode of sepsis between June 2018 and February 2025. Latent-class mixed models (LCMM) were used to identify SII trajectory subgroups, and Cox regression was used to analyze the relationship between subgroups and in-hospital mortality. An eXtreme Gradient Boosting (XGBoost) machine le

SUBMITTER: Xu W 

PROVIDER: S-EPMC12500555 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature