Association of lactate to albumin ratio with short-term and long-term mortality in critically ill patients with heart failure complicated by sepsis: a retrospective study using the MIMIC-IV database.

ABSTRACT:

Background

Elevated lactate to albumin ratio (LAR) has been associated with poor prognosis in critical illnesses. However, evidence regarding LAR in patients with heart failure (HF) complicated by sepsis remains limited. This study aimed to explore the relationship between LAR and both short-term and long-term mortality in this population.

Method

Patient data were extracted from the Medical Information Mart for Intensive Care (MIMIC-IV) database and stratified into quartiles based on LAR. The primary endpoints were 28-day and 365-day all-cause mortality. Kaplan-Meier survival analysis was performed to compare outcomes across the four groups. Association between LAR and mortality was assessed using restricted cubic splines (RCS) and Cox regression analysis. Additionally, subg

SUBMITTER: Wu Y 

PROVIDER: S-EPMC12500606 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature